This book provides an overview of the current knowledge on the epidemiology, etiology, diagnosing and staging of chronic lymphocytic leukemia (CLL), as well as the molecular and genetic aspects that underpin treatment and prognosis. It provides a concise overview of treatment options, in both the front-line and relapsed/refractory settings, with particular focus on the novel targeted agents that have overcome many adverse prognostic factors and improved overall survival. This resource will provide all members of the multidisciplinary team who care for patients with CLL with a strong foundation for understanding, diagnosing and managing CLL in the present and future.