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Immune surveillance is a mechanism by which the immune system identifies cancer cells and eliminates them via cytotoxic T-cells (CTLs). Tumors have developed strategies to escape immune surveillance including an altered expression of various immune checkpoints leading to the suppression of CTL function.ⁱ In normal tissues the PD-1/PD-L1 axis acts as a ‘brake’ in immune function preventing sustained T-cell activity and tissue damage.^u T-cells are activated via binding of the TCR to the MHC/antigen complex on an APC or tumor cell.^f Upon T-cell activation, PD-1 expression is induced.^X A tumor cell can upregulate PD-L1 expression to mimic normal cells and “turn off” T-cells to escape immune surveillance.^!al

Blocking the PD-1/PD-L1 signaling pathway by an anti-PD-1 antibody allows T-cells to maintain their effector functions.⁼ The Fc portion of the anti-PD-1 antibody and its limited interaction with FcγR are important for its therapeutic activities.⁸ Activated tumor-specific T-cells mediate the destruction of tumor cells and secrete cytokines that activate and recruit other immune cells to participate in the antitumor response.^; Anti-PD-1 antibodies, which bind to FcγRs, likely mediate the crosslinking between PD-1+ T cells and FcγR+ macrophages. Such crosslinking could potentially induce macrophages to phagocytize PD-1+ T cells and possibly diminish antitumor responses.⁸

Tislelizumab is a humanized IgG4 mAb with high affinity and binding specificity for PD-1.^Y Tislelizumab was specifically engineered to minimize binding to FcγR on macrophages.⁸ Minimal binding of anti-PD-1 antibodies to FcγR abrogates antibody-dependent cellular phagocytosis, a potential mechanism of T-cell clearance.^i$Nii Binding surface of tislelizumab on PD-1 overlapped largely with that of PD-L1, leading to the complete blockade of PD-1/PD-L1 interaction (>99%).^K|

For a complete list of tislelizumab monotherapy and combination clinical trials view the wp[p0&EJp7E vl4Ml{k.

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1. Zhang T et al. The binding of an anti-PD-1 antibody to FcγRΙ has a profound impact on its biological functions. DcM?7^ P44,`=2 d&&Uq]~})N. 2018;67:1079–1090.
2. Lu, S. et al. Tislelizumab Plus Chemotherapy as First-Line Treatment for Locally Advanced or Metastatic Nonsquamous NSCLC (RATIONALE 304): A Randomized Phase 3 Trial. R. *BPj4L. xq{Q1. 2021;16:1512–1522.
3. Ribatti D. The concept of immune surveillance against tumors: The first theories. X56-VrX@QV 2017; 8:7175-7180.
4. LaFleur MW, et al. Inhibitors of the PD-1 Pathway in Tumor Therapy. 2 3;;)7L) 2018 Jan 15; 200(2):375-383.
5. Tsai KK et al. PD-1 and PD-L1 antibodies for melanoma. Wvr-O ;R==wc!0 0-hmy l++e`Y^4/xzj/e^MiV 2014; 10:3111–3116
6. Mahoney KM et al. The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma 8mn{. r|@A 2015; 37:764–782.
7. Sznol M. Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer. ITc1 G=/X2n 8+k. 2013;1 9:1021–1034.
8. Waldman AD, et al. A guide to cancer immunotherapy: from T cell basic science to clinical practice. JMn G&1 1jj6#,9 2020; 20:651-668.
9. Desai J et al. Preliminary results from subsets of patients (pts) with advanced gastric cancer (GC) and esophageal carcinoma (EC) in a dose-escalation/expansion study of BGB-A317, an anti-PD-1 monoclonal antibody (mAb). M@@ kp^W` 2017; 28(suppl_5):v122–v141.
10. Arlauckas SP et al. In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy. 8H: z92;I~ XE/ 2017; 9:eaal3604.
11. Dahan R et al. FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis. $:{I?9 RMss 2015; 28:285–295.
12. Hong Y et al. Tislelizumab uniquely binds to the CC0loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage. ADuY 6|I} 5Y? 2021; 11(3):782-792