Network Meta-Analysis (NMA) methodology is explained in this video hosted by Dr Mazyar Shadman, MD, MPH, Associate Professor at Fred Hutch Cancer Centre and the University of Washington School of Medicine. This video covers how to connect three or more trials using common comparators to estimate relative efficacy outcomes. Highlights include the practical use of NMA, differences between MAIC and NMA, and a worked through example using the ASCEND, ALPINE, and ELEVATE-RR trials in relapsed/refractory CLL (R/R CLL). This video is aimed at those interested in advanced health research methods.