RX|XB#J7Xb: L[7g[fC

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X#=eFK O`Xi
V// uS;xP
yssn9ss
yssn9ss
0E
0E
@L@ bZ
@L@ bZ
AeA `~e
AeA `~e
HG NC]
HG NC]
^6^ \ke
^6^ \ke
T#T vtbUt f_r! E|YL6
T#T vtbUt f_r! E|YL6
n+#1:QE:-f $|fA$fv FY6688 ,bafe:b:Af/z
n+#1:QE:-f $|fA$fv FY6688 ,bafe:b:Af/z
k9Gd#9h dNdAe/~8U] ?(kgpjk:Ug4
k9Gd#9h dNdAe/~8U] ?(kgpjk:Ug4
wq$q_ CGJeU/:/w
wq$q_ CGJeU/:/w
9, /HHᵇ
9, /HHᵇ
A)A D@
A)A D@
VdV /DD
VdV /DD
:H: xx (Ozf FKLLnL3y
:H: xx (Ozf FKLLnL3y
LZwUZ(T
LZwUZ(T
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Js{J^^ |Oix^%O%-xkk
ePe N[} |jR 1T1 U__
ePe N[} |jR 1T1 U__
@$77;; :^#}G^^^F}8u
@$77;; :^#}G^^^F}8u
8{8 :1+
8{8 :1+
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=L= q2uh2
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(, (3[N? OLePep C1 3[. ][LRLq XraP :m@r@
yb i2ti0E2
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\J B/uu
\J B/uu
vk ?S\\
vk ?S\\
Z6 ;8T
Z6 ;8T
4v WNNp SQ/{ Muu
4v WNNp SQ/{ Muu
MJ [-;
MJ [-;
@K V8ff
@K V8ff
x2$d?XJ Zh/p/
x2$d?XJ Zh/p/
\Y \4-41b1
\Y \4-41b1
x+l1l *r*8|*~Q,L2*r RR[N|1C/7R?7
x+l1l *r*8|*~Q,L2*r RR[N|1C/7R?7
h| 2]R^6 u}~u fC,~,
h| 2]R^6 u}~u fC,~,
2eT8( 3ZCu3b
2eT8( 3ZCu3b
Ct Y&H |]8[Z L%@cQ=
Ct Y&H |]8[Z L%@cQ=
YuuL%!%
YuuL%!%
gg 9Jpll
gg 9Jpll
fO VqRkRᵃ
fO VqRkRᵃ
umC1+%~ 8FS\Sᵃ
umC1+%~ 8FS\Sᵃ
mi: 8!7#7ᵃ
mi: 8!7#7ᵃ
fi k`aWWᵃ
fi k`aWWᵃ
:q nPj,= k(+
:q nPj,= k(+
Us k]s$: h2G
Us k]s$: h2G
75 $Jj-a *UD?BD
75 $Jj-a *UD?BD
3xYZNL2Z) 344L #S
3xYZNL2Z) 344L #S
C( srR :=~#v3 ;V}S
C( srR :=~#v3 ;V}S
}1:fA|v1 o9+)P+$ 5s*5mD
}1:fA|v1 o9+)P+$ 5s*5mD
78 Q&6&
78 Q&6&
N)PQ2P26)6 L9!9S9^S9z! {6!~h~!~Mvn
N)PQ2P26)6 L9!9S9^S9z! {6!~h~!~Mvn
97e7O9O H/d/|/6|/Yd s8A%l%A%#D#
97e7O9O H/d/|/6|/Yd s8A%l%A%#D#
{/= i]D]
{/= i]D]
lyxCy
lyxCy
MRELyZ3L| BUB cuVT?? _rEr^rK^rAE ^TjXFXjX4GO
MRELyZ3L| BUB cuVT?? _rEr^rK^rAE ^TjXFXjX4GO
5sHmgo u]5 !UKH[E[K g=Hgq`
5sHmgo u]5 !UKH[E[K g=Hgq`
*%kqz
@22 2MS4P4
S
S
i
i
(
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X#=eFK O`Xi
V// uS;xP
yssn9ss
yssn9ss
0E
0E
@L@ bZ
@L@ bZ
AeA `~e
AeA `~e
HG NC]
HG NC]
^6^ \ke
^6^ \ke
T#T vtbUt f_r! E|YL6
T#T vtbUt f_r! E|YL6
n+#1:QE:-f $|fA$fv FY6688 ,bafe:b:Af/z
n+#1:QE:-f $|fA$fv FY6688 ,bafe:b:Af/z
k9Gd#9h dNdAe/~8U] ?(kgpjk:Ug4
k9Gd#9h dNdAe/~8U] ?(kgpjk:Ug4
wq$q_ CGJeU/:/w
wq$q_ CGJeU/:/w
9, /HHᵇ
9, /HHᵇ
A)A D@
A)A D@
VdV /DD
VdV /DD
:H: xx (Ozf FKLLnL3y
:H: xx (Ozf FKLLnL3y
LZwUZ(T
LZwUZ(T
Js{J^^ |Oix^%O%-xkk
Js{J^^ |Oix^%O%-xkk
ePe N[} |jR 1T1 U__
ePe N[} |jR 1T1 U__
@$77;; :^#}G^^^F}8u
@$77;; :^#}G^^^F}8u
8{8 :1+
8{8 :1+
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=L= q2uh2
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(, (3[N? OLePep C1 3[. ][LRLq XraP :m@r@
yb i2ti0E2
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\J B/uu
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vk ?S\\
Z6 ;8T
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4v WNNp SQ/{ Muu
4v WNNp SQ/{ Muu
MJ [-;
MJ [-;
@K V8ff
@K V8ff
x2$d?XJ Zh/p/
x2$d?XJ Zh/p/
\Y \4-41b1
\Y \4-41b1
x+l1l *r*8|*~Q,L2*r RR[N|1C/7R?7
x+l1l *r*8|*~Q,L2*r RR[N|1C/7R?7
h| 2]R^6 u}~u fC,~,
h| 2]R^6 u}~u fC,~,
2eT8( 3ZCu3b
2eT8( 3ZCu3b
Ct Y&H |]8[Z L%@cQ=
Ct Y&H |]8[Z L%@cQ=
YuuL%!%
YuuL%!%
gg 9Jpll
gg 9Jpll
fO VqRkRᵃ
fO VqRkRᵃ
umC1+%~ 8FS\Sᵃ
umC1+%~ 8FS\Sᵃ
mi: 8!7#7ᵃ
mi: 8!7#7ᵃ
fi k`aWWᵃ
fi k`aWWᵃ
:q nPj,= k(+
:q nPj,= k(+
Us k]s$: h2G
Us k]s$: h2G
75 $Jj-a *UD?BD
75 $Jj-a *UD?BD
3xYZNL2Z) 344L #S
3xYZNL2Z) 344L #S
C( srR :=~#v3 ;V}S
C( srR :=~#v3 ;V}S
}1:fA|v1 o9+)P+$ 5s*5mD
}1:fA|v1 o9+)P+$ 5s*5mD
78 Q&6&
78 Q&6&
N)PQ2P26)6 L9!9S9^S9z! {6!~h~!~Mvn
N)PQ2P26)6 L9!9S9^S9z! {6!~h~!~Mvn
97e7O9O H/d/|/6|/Yd s8A%l%A%#D#
97e7O9O H/d/|/6|/Yd s8A%l%A%#D#
{/= i]D]
{/= i]D]
lyxCy
lyxCy
MRELyZ3L| BUB cuVT?? _rEr^rK^rAE ^TjXFXjX4GO
MRELyZ3L| BUB cuVT?? _rEr^rK^rAE ^TjXFXjX4GO
5sHmgo u]5 !UKH[E[K g=Hgq`
5sHmgo u]5 !UKH[E[K g=Hgq`
*%kqz
@22 2MS4P4
S
S
i
i
(
(
k6+u67)1
VqE4@E4 O4=p &f [808I[$F
*%kqz
+hl|o3|u%l%o S k[N {[}{:{V`G
yssn9ss
S
E=F7xKf71=8
yssn9ss
0E
S
E=F7xKf71=8
0E
@L@ bZ
S
E=F7xKf71=8
@L@ bZ
AeA `~e
S
E=F7xKf71=8
AeA `~e
HG NC]
S
E=F7xKf71=8
HG NC]
^6^ \ke
i
E=F7xKf71=8
^6^ \ke
T#T vtbUt f_r! E|YL6
i
E=F7xKf71=8
T#T vtbUt f_r! E|YL6
n+#1:QE:-f $|fA$fv FY6688 ,bafe:b:Af/z
i
E=F7xKf71=8
n+#1:QE:-f $|fA$fv FY6688 ,bafe:b:Af/z
md:gWygUZ:ZW -;DDvj?G?B& |(S*a Hq%;4::4{i/q6 K ~5E QSuQ{Q0Y2
k9Gd#9h dNdAe/~8U] ?(kgpjk:Ug4
S
E=F7xKf71=8
k9Gd#9h dNdAe/~8U] ?(kgpjk:Ug4
wq$q_ CGJeU/:/w
i
E=F7xKf71=8
wq$q_ CGJeU/:/w
20Lf0u0Km\f A |B3b -|8-V-9yD
9, /HHᵇ
S
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9, /HHᵇ
A)A D@
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A)A D@
VdV /DD
i
E=F7xKf71=8
VdV /DD
^6^ \ke
i
E=F7xKf71=8
^6^ \ke
:H: xx (Ozf FKLLnL3y
(
E=F7xKf71=8
:H: xx (Ozf FKLLnL3y
LZwUZ(T
(
E=F7xKf71=8
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Js{J^^ |Oix^%O%-xkk
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E=F7xKf71=8
Js{J^^ |Oix^%O%-xkk
c`cjxHHQ? c =|$F%KZFV%V! !;=!
Js{J^^ |Oix^%O%-xkk
(
E=F7xKf71=8
Js{J^^ |Oix^%O%-xkk
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i
E=F7xKf71=8
ePe N[} |jR 1T1 U__
_Z_4hZ;;n D Eylo Ag3A)AH{=
@$77;; :^#}G^^^F}8u
(
E=F7xKf71=8
@$77;; :^#}G^^^F}8u
JOdy&yO[:FGH / kIYLRu9R;
8{8 :1+
S
E=F7xKf71=8
8{8 :1+
:7B\Y*YBdMn : JOc,tR1@1R
=L= q2uh2
(
E=F7xKf71=8
=L= q2uh2
JOdy&yO[:FGH / kIYLRu9R;
(, (3[N? OLePep C1 3[. ][LRLq XraP :m@r@
S
E=F7xKf71=8
(, (3[N? OLePep C1 3[. ][LRLq XraP :m@r@
yb i2ti0E2
S
E=F7xKf71=8
yb i2ti0E2
\J B/uu
S
E=F7xKf71=8
\J B/uu
vk ?S\\
S
E=F7xKf71=8
vk ?S\\
Z6 ;8T
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E=F7xKf71=8
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4v WNNp SQ/{ Muu
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E=F7xKf71=8
4v WNNp SQ/{ Muu
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S
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x2$d?XJ Zh/p/
S
E=F7xKf71=8
x2$d?XJ Zh/p/
\Y \4-41b1
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\Y \4-41b1
x+l1l *r*8|*~Q,L2*r RR[N|1C/7R?7
(
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x+l1l *r*8|*~Q,L2*r RR[N|1C/7R?7
:7B\Y*YBdMn : JOc,tR1@1R
h| 2]R^6 u}~u fC,~,
S
E=F7xKf71=8
h| 2]R^6 u}~u fC,~,
2eT8( 3ZCu3b
(
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2eT8( 3ZCu3b
o~IXZ2k|¹ 3 }61? (W*([(RfK
Ct Y&H |]8[Z L%@cQ=
(
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Ct Y&H |]8[Z L%@cQ=
(
E=F7xKf71=8
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ju&j]TWb² U @&Dso1Nd
Ct Y&H |]8[Z L%@cQ=
(
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i
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YuuL%!%
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i
E=F7xKf71=8
\J B/uu
8;{Mg\p&6pR9\ m |?1JT*Z17
gg 9Jpll
i
E=F7xKf71=8
gg 9Jpll
~?rbPPP5 p 6] zv|QF#P$Fv#e
fO VqRkRᵃ
i
E=F7xKf71=8
fO VqRkRᵃ
umC1+%~ 8FS\Sᵃ
i
E=F7xKf71=8
umC1+%~ 8FS\Sᵃ
mi: 8!7#7ᵃ
i
E=F7xKf71=8
mi: 8!7#7ᵃ
fi k`aWWᵃ
i
E=F7xKf71=8
fi k`aWWᵃ
~sFYxsIs5sM⁴ t 4nPz[n(0W tD=}
:q nPj,= k(+
i
E=F7xKf71=8
:q nPj,= k(+
Us k]s$: h2G
S
E=F7xKf71=8
Us k]s$: h2G
75 $Jj-a *UD?BD
(
E=F7xKf71=8
75 $Jj-a *UD?BD
}}}-FMM+ _ Lnpb*-FQC
3xYZNL2Z) 344L #S
i
E=F7xKf71=8
3xYZNL2Z) 344L #S
!L!+9M7#M ~ =a-t _~%_o_ZI%
2eT8( 3ZCu3b
(
E=F7xKf71=8
2eT8( 3ZCu3b
2j2H4xxlx \ u~MT hkShah{3\
2eT8( 3ZCu3b
(
E=F7xKf71=8
2eT8( 3ZCu3b
KZK!7j)8j j ~yL3 ,H,i_H/
2eT8( 3ZCu3b
(
E=F7xKf71=8
2eT8( 3ZCu3b
;v;hkq9vk Z M@Oζ DhjD_Dugj
2eT8( 3ZCu3b
(
E=F7xKf71=8
2eT8( 3ZCu3b
txtEp^T__ 2 E{M\811A6
2eT8( 3ZCu3b
(
E=F7xKf71=8
2eT8( 3ZCu3b
x(xp|)|PP % )$5~δ J%GJMJL+4
2eT8( 3ZCu3b
(
E=F7xKf71=8
2eT8( 3ZCu3b
z]^&`]g&u I ~+A~ iO] e@Xe{e9fT
C( srR :=~#v3 ;V}S
S
E=F7xKf71=8
C( srR :=~#v3 ;V}S
}1:fA|v1 o9+)P+$ 5s*5mD
i
E=F7xKf71=8
}1:fA|v1 o9+)P+$ 5s*5mD
k~K{~0~M~0 G tddD k `Uw
78 Q&6&
S
E=F7xKf71=8
78 Q&6&
N)PQ2P26)6 L9!9S9^S9z! {6!~h~!~Mvn
S
E=F7xKf71=8
N)PQ2P26)6 L9!9S9^S9z! {6!~h~!~Mvn
97e7O9O H/d/|/6|/Yd s8A%l%A%#D#
S
E=F7xKf71=8
97e7O9O H/d/|/6|/Yd s8A%l%A%#D#
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(
E=F7xKf71=8
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lyxCy
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MRELyZ3L| BUB cuVT?? _rEr^rK^rAE ^TjXFXjX4GO
i
E=F7xKf71=8
MRELyZ3L| BUB cuVT?? _rEr^rK^rAE ^TjXFXjX4GO
G_:)S)3Op Hp$#)USTy#yU⁶ c ^%ji J4hl7}Q
5sHmgo u]5 !UKH[E[K g=Hgq`
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E=F7xKf71=8
5sHmgo u]5 !UKH[E[K g=Hgq`

}; Zv _qX H]H6

(Ensem collaboration; BeiGene has global rights. iDualityBio collaboration; BeiGene has global rights. SLeads Biolabs collaboration; BeiGene has ex-China commercial rights. %May include anti-PD-1, anti-LAG3, anti-OX40, and HPK1 inhibitor. tZymeworks/Jazz collaboration; BeiGene has APAC/ex Japan, AU, and NZ commercial rights. SAmgen collaboration; BeiGene has China commercial rights. fLuye collaboration; BeiGene has China rights. H in combination with Zanubrutinib.

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