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First-line treatment of patients with CLL: The end of chemotherapy?

Francesc Bosch, Stephan Stilgenbauer and Alessandra Tedeschi discuss the first-line treatment of patients with CLL, including the role of first-line chemotherapy and selecting continuous vs time-limited targeted therapy.

Duration: 01:30:57 View full-length webinar
Video
22 Nov 2022
CLL
BTKi
BCL2i
Speakers

Alessandra Tedeschi

Stephan Stilgenbauer

Francesc Bosch

First-line treatment for patients with CLL

Alessandra Tedeschi

Duration: 31:57
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When to treat patients with CLL?
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Early intervention vs. observation
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Treatment selection
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Covalent BTKis
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Venetoclax and obinutuzumab
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Is there still a role for FCR in first-line CLL?
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Treatment of patients with del(17p)/TP53mut
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Conclusions: First-line treatment of CLL
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Time-limited vs. continuous targeted therapy in CLL

Stephan Stilgenbauer

Duration: 13:54
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First-line BTKi-based therapy vs. CIT
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BTKi therapy for del(17p) / TP53mut
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Ibrutinib AEs and treatment discontinuation
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Next-generation BTKis
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Venetoclax-based regimens
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Patient characteristics, disease parameters and treatment goals
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Conclusions: Time-limited vs. continuous targeted therapy
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Panel discussion & audience Q&A

Francesc Bosch,

Stephan Stilgenbauer,

Alessandra Tedeschi

Duration: 41:44
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Fast-forward to:
Is fitness irrelevant for CLL patients with del(17p)?
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Challenges with venetoclax and obinutuzumab
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What is the role of transplant in patients with del(17p)/TP53mut/complex karyotype after targeted therapy?
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How do you manage switching a patient from ibrutinib to a next-generation BTKi?
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Management of immunosuppression and infections in the COVID-19 era
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How effective is retreatment for patients who relapse on fixed-duration venetoclax regimens?
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Sequencing of therapies
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The role of ibrutinib + venetoclax
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