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Challenges in the diagnosis, staging, and clinical work up of Waldenström’s macroglobulinemia (WM): A practical guide to current best practice
Christian Buske, Alessandra Tedeschi and Roger Owen chart the diagnostic journey in Waldenström’s macroglobulinemia, covering topics such as diagnostic criteria, techniques for testing, differential diagnoses, staging and the impact of specific disease-associated mutations.
Speakers
Diagnosing a patient with WM
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What are the diagnostic considerations and clinical features for patients presenting with WM symptoms?
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What is WM?
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WM cell morphology
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The WM-specific immunophenotype
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The implication of genotypes in WM
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Is it WM, MGUS or IgM myeloma?
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Key diagnostic assessments when considering WM
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Case study
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Debate
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Q&A
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When you have a high-quality bone marrow aspirate, is a bone marrow biopsy necessary for diagnosis?
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How do you differentiate marginal zone lymphoma with IgM versus WM?
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Do you test for amyloidosis in the bone marrow biopsies of patients with WM? Should this be done routinely for WM patients or only when amyloidosis is suspected clinically?
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What proportion of patients with WM have neuropathy as their primary symptom? What is your favoured treatment choice for neuropathy for patients with WM?
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How does a p53 gene mutation affect your treatment strategy for a patient with WM?
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What would be your favoured treatment for a medically unfit elderly patients with WM?
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Would you deny BTK inhibitor therapy to a WM patient who is wild-type for both MYD88 and CXCR4 genes?
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Does WM exist in association with production of immunoglobulins other than IgM, such as IgG or IgA? How are these patients treated?
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When there is amyloid in the bone marrow biopsy do you look at serum free light chain levels?
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